Prof. John Common

Professor John Common

Professor of Cutaneous Inflammation & Microbiome
Newcastle University

Biography

Professor John Common is a skin scientist whose work focuses on skin barrier biology, inflammatory skin disease, and host–microbe interactions. He completed his PhD at Queen Mary University of London before spending 20 years at A*STAR in Singapore, where he established major programmes in skin genetics, cell biology and microbiome research.
In 2024 he was appointed Professor of Cutaneous Inflammation & Microbiome at Newcastle University, returning to the North East where he grew up. His research bridges fundamental discovery with translational applications, including mechanisms related to inflammatory skin diseases, skin microbiomes, and rare skin diseases.

Contributions to Newcastle Dermatology Research

Professor Common leads research into:

  • Skin genetics and barrier dysfunction – including pioneering sequencing approaches for filaggrin and other epidermal differentiation complex genes.
  • Skin microbiome and metatranscriptomics – developing methods to understand microbial gene activity and host–microbe interactions in atopic dermatitis, acne, and other skin conditions.
  • Novel therapeutics – exploring RNA-based treatments, and vaccines for inflammatory and infectious skin diseases.
  • Translational research capacity – building collaborative pipelines that link laboratory discovery, 3D skin models, and clinical dermatology at Newcastle.

Through these research goals we aim to position Newcastle as a centre for excellence in skin research, with strong academic–industry partnerships and international collaborations.

Selected Publications

01
Chia M#, Ng Hui Qi A, Ravikrishnan A, Mohamed Naim AN, Wearne S, Common J, Nagarajan N#. (2025) Skin metatranscriptomics reveals landscape of variation in microbial activity and gene expression across the human body. Nature Biotechnology. Aug 28:1-2.
02
Li C, Ravikrishnan A, Wijaya I, Naim ANM … Common J#, Nagarajan N#. Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites. bioRxiv 2025.04.24.650393
03
Rozario P, Lim YS, Ding SSL, … Common JE#, Zhong FL#. IFNγ priming enables NLRP3 inflammasome activation in human keratinocytes in vitro. J Invest Dermatol. 2025 Dec 11:S0022-202X(25)03630-9. doi: 10.1016/j.jid.2025.11.019.
04
Common, JE. # & Payne RP. Microbial Makeover: Skin microbiome reset after stem cell transplantation. Cell Host & Microbe. Aug 13;33(8):1318-20.
05
Koh LF, Firdaus MJ, Natsuaki Y, Hanakawa S, Tham KC, Lunny DP, Yap BLH, Nakamizo S, Nam E, Lee JE, Toh YX, Teo NMH, Lim TC, Lane EB, Kabashima K, Janela B, Common JE.# Ruxolitinib Alleviates Inflammation and Fortifies Skin Barrier Function Through Dampening IL-13. Exp Dermatol. 2025 Jul;34(7):e70132.
06
Eisner M, Sharkey T, Common J, Rajan N. Comment on ‘A proposal for a new pathogenesis-guided classification for inherited epidermal differentiation disorders’. British Journal of Dermatology. 2025 Apr 28:ljaf145.
07
Puppels GJ, Hourihane JO, Nico C, Chaoimh CN, Wong C, Common JE, Caspers PJ, Irvine AD. Highly accurate, noninvasive early identification of infants with a filaggrin loss-of-function mutation by in vivo Raman spectroscopy, followed from birth to 12 months. Annals of Allergy, Asthma & Immunology. 2025 Apr 1;134(4):457-64.
08
Tham KC, Lim SS, Bonnard C, Common JE.# Protocol to reconstruct an in vitro 3D full-thickness skin equivalent model with collagen I in 6-and 12-well inserts. STAR Protocols. 2025 Mar 21;6(1):103658.
09
Gorse L, Plessis L, Wearne S, Paradis M, Pinilla M, Chua R, Lim SS, Pelluz E, Toh GA….. Common J,# Etienne Meunier E,# Philipp Hess# (2025) Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation. EMBO Molecular Medicine. Feb 13:1-28.
10
Vind AC, Wu Z, Firdaus MJ, Snieckute G, Toh GA, Jessen M, Maartensson NL, Common JEA, Gyrd-Hansen M, Zhong FL, Bekker-Jensen S#. (2024). The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo. Molecular Cell. Nov 25:S1097-2765(24)00884-0.